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Since the development of Fmoc-based solid phase peptide synthesis, a wide variety of cleavage cocktails have emerged. Each cleavage cocktail contains a unique combination of scavengers designed to prevent either side reactions mediated by the released protecting groups or the side chains themselves, or both during the peptide cleavage reaction. As the number of scientists performing peptide synthesis grows, the question “which cleavage cocktail should I use?” comes up more often than not.
In today’s post, I’ll highlight the role of of scavengers for peptides containing cysteine residues.
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