Using microwave heating to expedite your allyl ester or alloc deprotection

Orthogonal amino acid protecting groups effectively expand the chemical tool kit available to peptide chemists allowing for synthesis of much more complex molecules.  Often times, orthogonal protecting groups are used in Fmoc-based chemistry to facilitate post-synthesis modifications of peptides, like the addition of small molecule fluorophores and more commonly now, peptide cyclization efforts.

In a previous post, I discussed optimizing the removal of an ivDde protecting group.  In today’s post, I’ll explore the removal of an alloc protecting group from a lysine residue.

Read More Here!

2 thoughts on “Using microwave heating to expedite your allyl ester or alloc deprotection”

  1. interesting. It would be interesting to see a comparison with different (lower) equivalents of Pd with and without microwave. Also a similar study where a secondary amine is used instead of silane as scavenger.

    1. Hello Raffaele,
      Thanks for your comment and for the time to read my blog. I am actually planning some work evaluating conditions at room temperature for an upcoming post, but your thoughts on a secondary amine scavenger is very interesting! I’ll definitely look into that for the future.

Leave a Reply

Your email address will not be published. Required fields are marked *