Tips, tricks and insights about all things solid phase peptide synthesis – a blog by Biotage
Using microwave heating to expedite your allyl ester or alloc deprotection
Orthogonal amino acid protecting groups effectively expand the chemical tool kit available to peptide chemists allowing for synthesis of much more complex molecules. Often times, orthogonal protecting groups are used in Fmoc-based chemistry to facilitate post-synthesis modifications of peptides, like the addition of small molecule fluorophores and more commonly now, peptide cyclization efforts.
In a previous post, I discussed optimizing the removal of an ivDde protecting group. In today’s post, I’ll explore the removal of an alloc protecting group from a lysine residue.