Tips, tricks and insights about all things solid phase peptide synthesis – a blog by Biotage
Optimizing the removal of an ivDde protecting group
As the complexity of peptides continues to grow, so does the use of amino acids with side chain protecting groups that can be selectively removed, leaving the peptide on resin and the remaining side chain protecting groups intact. While there are protocols to be found in the literature, they may not work to the highest level of efficiency every single time. This can lead to disasterous results for any subsequent chemistry.
In today’s post, I’ll evaluate a variety of conditions for removing an ivDde protecting group.